Here is the premise of the movie according to imdb...
Drama is set in 1954, U.S. Marshal Teddy Daniels is investigating the disappearance of a murderess who escaped from a hospital for the criminally insane and is presumed to be hiding on the remote Shutter Island.

Whammy!
I tell ya, Scorsese really knows how to use the frame. I've noticed it before but I have to say, he mastered it this time (And this is just the trailer!). I bet the Academy is kicking their own butt for giving him Best Directer for The Departed. Doubt it actually, That movie rocks.
I found the trailer to be suspenseful and eerie. He has to be nodding to Hitchcock in this one. Plus, this gets me thinking about the Best Actor race. If DDL (Nine) and Leo are up, based on the trailers, I'd have to go Leo on this one for sure. I just hope it isn't one of those twist ending movies where Leo ends up being the 67th patient. Lets hope the movie lives up to what we just watched!